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Therapy: Stem Cell Therapy
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Altered Sca-1+ Progenitor Cell Populations in Diabetic Mice Are Associated with Increased Neointimal Hyperplasia After Vascular Injury
Diabetic patients exhibit poor outcomes after vascular interventions, predominantly due to development of neointimal hyperplasia. While diabetic mice have been shown to have diminished Sca-1+ stem cells in their bone marrow, the role of Sca-1+ cells in the vasculature is unknown. We hypothesize that diabetic mice have diminished Sca-1+ stem cell populations in the arterial wall compared with wild type (WT) mice. We also hypothesize that vascular injury will alter the presence and distribution of Sca-1+ cells in the arterial wall.
Source: Journal of Vascular Surgery - October 28, 2013 Category: Surgery Authors: Jill R. Streams, Janet Martinez, Megan Flynn, Melina R. Kibbe Tags: Abstracts from the 2013 Midwestern Vascular Surgical Society Annual Meeting Source Type: research
Prospects for applications of stem cells in vascular surgery
Source: Jornal Vascular Brasileiro - October 31, 2016 Category: Surgery Source Type: research
Extracellular Matrix Remodeling in Vascular Disease: Defining Its Regulators and Pathological Influence
Arterioscler Thromb Vasc Biol. 2023 Jul 6. doi: 10.1161/ATVBAHA.123.318237. Online ahead of print.ABSTRACTBecause of structural and cellular differences (ie, degrees of matrix abundance and cross-linking, mural cell density, and adventitia), large and medium-sized vessels, in comparison to capillaries, react in a unique manner to stimuli that induce vascular disease. A stereotypical vascular injury response is ECM (extracellular matrix) remodeling that occurs particularly in larger vessels in response to injurious stimuli, such as elevated angiotensin II, hyperlipidemia, hyperglycemia, genetic deficiencies, inflammatory ce...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 6, 2023 Category: Cardiology Authors: Prisca K Lin George E Davis Source Type: research
Vascular adhesion protein-1 (VAP-1) in vascular inflammatory diseases
Vasa. 2022 Oct 6. doi: 10.1024/0301-1526/a001031. Online ahead of print.ABSTRACT Vascular adhesion protein-1 (VAP-1) also known as amino oxidase copper containing 3 (AOC3) is a pro-inflammatory and versatile molecule with adhesive and enzymatic properties. VAP-1 is a primary amine oxidase belonging to the semicarbazide-sensitive amine oxidase (SSAO) family, which catalyzes the oxidation of primary amines leading to the production of ammonium, formaldehyde, methylglyoxal, and hydrogen peroxide. VAP-1 is mainly expressed by endothelial cells, smooth muscle cells, adipocytes and pericytes. It is involved in a repertoire of bi...
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - October 6, 2022 Category: Surgery Authors: Marianna Danielli Roisin Clare Thomas Lauren Marie Quinn Bee Kang Tan Source Type: research
